Welche Antibiotika gehören zu den aminoglykoside?
Aminoglykosid-Antibiotika sind eine heterogene Gruppe von Oligosaccharid-Antibiotika….Es gibt folgende Gruppen von Aminoglykosid-Antibiotika:
- Streptomycin-Gruppe (Streptomycin)
- Neomycin-Gruppe (Neomycin und Paromomycin I)
- Kanamycin-Gruppe (Kanamycin, Tobramycin)
- Gentamicin-Gruppe (Gentamicin, Netilmycin)
- Spectinomycin.
Wie wirken aminoglykoside?
Aminoglykoside wirken auf ruhende und proliferierende Erreger bei aerober Stoffwechsellage durch Hemmung der ribosomalen Proteinbiosynthese und Bildung von „Nonsens“-Proteinen. Sie zeigen eine starke konzentrationsabhängige bakterizide Wirkung mit einem ausgeprägten postantibiotischen Effekt.
What are the different types of aminoglycoside antibiotics?
Here is a list of nine aminoglycoside antibiotics. 1. Streptomycin: 1. Isolated from streptomyces griseus in 1943. 2. Very soluble in water. 3. Stable compared with penicillin. 4. Pure dry powder remain full potency at room temperature for at least 2 years. 5. Intestinal absorption poor. 6. Used in the treatment of enteritis.
When are aminoglycosides given IM or IV?
Aminoglycosides are usually given IV but may be given IM if IV access is unavailable. Aminoglycosides are distributed well into ECF except for vitreous humor, CSF, respiratory secretions, and bile (particularly in patients with biliary obstruction).
What is the highest dose of amikacin for Gram negative infection?
Dosing for Aminoglycoside High Dose Extended Interval Method For treatment of severe Gram-negative infections, dose recommended for gentamicin or tobramycin is 7 mg/kg and dose recommended for amikacin is 20mg/kg Use Total Body Weight (TBW) if Total Body Weight is less than 1.2 x Ideal Body Weight (IBW)
What are the contraindications for aminoglycosides?
Aminoglycosides are contraindicated in patients who are allergic to them. With aminoglycosides, there is evidence of risk to the fetus (eg, auditory toxicity), but clinical benefits may outweigh risk.